How to Resolve Sending Outlook Error 0x80040201 – Full Guide

Summary: This blog post provides a detailed overview of Outlook Error 0x80040201. Moreover, we discuss the error symptoms, causes, and solutions. Afterward, users can quickly and easily troubleshoot and fix Outlook Error 0x80040201 quickly and easily.

Outlook Error 0x80040201 is an error code that usually appears when users try to send an email in Outlook. This error occurs when a problem with the Outlook client itself, a problem with the Outlook profile, or an issue with the user’s internet connection or email server. In some cases, the error is related to Microsoft Exchange Server, a software used to store and manage emails.

The most common cause of this error is a problem with the Outlook client. The Outlook client can be configured incorrectly, or it may be corrupted. To resolve this issue, users should check the Outlook settings and make sure they are correct. First, we will discuss the different types of causes and then check the solutions.

What Reasons Behind the Outlook Error 0x80040201?

  • The cause of Outlook Error 0x80040201 is usually due to a corrupt or damaged PST file.
  • An incorrect Outlook setting.
  • Antivirus or firewall blocks the connection.
  • An incorrect server name or port number.
  • It can also arise due to an incorrect Outlook profile.
  • A damaged Outlook profile or an incorrect Outlook configuration.

Outlook Error 0x80040201

Methods to Resolve Outlook Unknown Error 0x80040201

Microsoft Outlook users frequently run into the issue known as the Outlook Unknown Error 0x80040201. The error can also happen when accessing Outlook data files, but it typically happens when sending or receiving emails. This guide offers a few solutions to fix this issue.

Method 1: Clear AutoComplete cache in Outlook

Users can use this feature instead of manually typing the full address when they email someone. From time to time, caches may be of some use to you. Moreover, on other occasions, it is appropriate to clear them away. In this overview, we will show you the proper way to clear away caches.

Option 1: Delete the NK2 File for older version

  1. First, open the Run dialog box using the Window+R key.
  2. Type this command %APPDATA%\Microsoft\Outlook in the dialog box.
  3. Now, find the NK2 extension file and delete it from your system.

Option 2: Clear AutoComplete cache For 2010 or above version

  1. In the Outlook app, click on the File menu.
  2. Go to Options and select Mail.
  3. Click on the Empty Auto-Complete List button.
  4. Press the OK button.

Method 2: Turn Off Faulty Add-ins

Sometimes, faulty add-ins can slow your Outlook and system as well. If you can’t remove these add-ins from Outlook, the application behaves unusually. However, you must disable or remove the add-ins from Outlook.

  1. Using the top bar or menu, go to the File menu.
  2. Pick the Options and then click on the Add-ins.
  3. Select the Manage option present at the Window bottom.
  4. Click on the Go button.
  5. Here, you’ll see the list of add-ins.
  6. To disable add-ins, uncheck the box of the add-in.
  7. Please select the Add-in and click on the Remove button to delete it.
  8. Finally, click on OK.
  9. Restart the Microsoft Outlook application.

Method 3: Use Outlook in Safe Mode

After removing faulty add-ins, you can restart your Outlook application. If the application doesn’t work, then open the application in safe mode.

  1. Press the Window+R key to bring the Run dialog box.
  2. Type Outlook.exe /safe in the text box.

Method 4: Create New Outlook Profile

If your application is not running properly and the Outlook Error 0x80040201 occurs. Then, you cannot send and receive emails due to a invalid Outlook profile.

Go through the following steps described below to create a new Outlook profile.

  1. Launch the Outlook application on your system.
  2. In the Outlook app, click on File.
  3. Under the Info section, click on Account Settings.
  4. Now select Manage Profiles.
  5. Here, click on the Show Profiles button.
  6. Click on the Add button, and input the name of the Profile. Press the OK button.
  7. When the window pop-up on your screen. Click on the Finish button after the successful account configuration.
  8. Now, check the option of Always use this profile.
  9. Hit the OK button.

Method 5: Turn-Off Antivirus

Antivirus software protects your operating system in a variety of ways. It can delete useless files and free up many junk files from your computer. In addition, the software not only defragments your drive and speeds it up.

To learn how you can uninstall antivirus on windows, here are all the relevant steps:

  1. Close all open programs on the system.
  2. Double-Click the notification icon or system tray.
  3. Now, click on the Antivirus software.
  4. In the antivirus app, look for an option to disable antivirus software, such as “Disable,” “Turn Off,” or “Exit.”
  5. Follow the further steps to disable the antivirus if prompted on your screen.

Method 6: Repair Corrupted Outlook File

  1. Copy and Paste this path on the address bar of the folder (the path can be different according to the Outlook version).
    1. C:\Program Files x86\Microsoft Office\{Office version}
  2. Navigate the SCANPST.EXE file in this folder.
  3. Using the Browse button, choose the default Outlook PST file.
  4. Click on the Start. Here, the in-built tool will scan all errors.
  5. If the PST file has any errors or is corrupted, you have to repair the PST file.
  6. Hit on the Repair button, and it will start the repair process.


In conclusion, Outlook Error 0x80040201 is a common error to troubleshoot. There are a variety of different issues that can cause it. However, by taking the steps outlined in this article, you can identify and resolve the cause of the error. If these steps do not help, contact Microsoft Support for more assistance.

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Sofia Smith is a technical content writer who has followed her passion for technology by authoring tech content at Sysvpro. Follow her on Twitter